Basic Info.
Certification
CE, GMP, ISO
Material
Stainless Steel 304 316
Working Pressure
ATM., Negative Pressure, Positive Pressure
Solvent
Methanol, Ethanol, Acetone and Other Organic Solve
Production Capacity (L/H)
5L/H~1000L/H
Type
Crude Drug Equipment
Finished Dosage Form
Liquid
Precision
Normal Precision
Computerized
Non-Computerized
Transport Package
Standard Wooden Packing
Origin
Zhejiang, China (Mainland)
Product Description
Chromatography equipment/ Resin adsorption column1. Product IntroductionThe chromatographic process is a new separation and purification process, which uses special adsorbents to selectively adsorb the effective components from plant extracts and remove the invalid components. It can solve the practical problems in the production of plant extracts, such as high dosage, moisture absorption and heavy metal residues. The refined products obtained by chromatographic treatment can enrich the active ingredients highly with less impurities, and the extraction yield is only 2-5% of the original organism, while the conventional boiling method is about 30% and the alcohol precipitation method is about 15%. It can effectively remove moisture absorption components and enhance the stability of products, and can effectively remove heavy metals. The extracts obtained by chromatographic separation process are small in volume, moisture-free and easy to be made into various dosage forms with beautiful appearance, especially suitable for the production of granules, capsules, tablets, etc. This technology will be one of the technological advances that have the greatest impact on the extraction process of traditional Chinese medicine and have the broadest driving force. Industrial preparation for separation, purification, design and manufacture in the fields of bioengineering, pharmaceutical industry and fine chemical industry. It has the characteristics of high resolution, good selectivity, continuous flow, high efficiency, stable treatment, more or less samples and easy operation. It is suitable for the separation and purification of complex macromolecule substances with less content. It is also used for the separation of active ingredients of Chinese herbal medicine, chemical synthetic medicine and biological active substances. Core equipment for purification.2. Product Characteristics2.1 Reasonable height-diameter ratio, precise fluid distribution device at inlet and outlet can ensure the filling effect and packing regeneration effect of the chromatography equipment, which provides a guarantee for efficient separation.2.2 The products are made of 304, 316L stainless steel and polished inside and outside. They are corrosion resistant, long service life, high hardness, safe transportation and guaranteed quality.2.3 This equipment ensures no pollution, high efficiency and easy operation.3. Operating process parameter table: STEP | SPEED | FLOW | REMARKS |
Filling charge | | | |
Countercurrent cleaning | | | Removal of small particles and crushed resin by washing |
Pre-processing | 1-5BV/h | 3BV | Pretreatment with ethanol, etc. |
Adsorbent | 1-4BV/h | According to the amount of adsorption | It should be below adsorption capacity, PH=5-8, temperature below 50ºC |
Washing | 2-3BV/h | 0.5-1BV | Wash out the impurities adsorbed on the resin |
desorption | 0.5-3BV/h | 2-3BV | Ethanol, acetone, etc. (aqueous) solution dissolves active ingredients, and high temperature is favorable for desorption. |
regenerate | 0.5-3BV/h | 3-4BV | Acid-base regeneration, elution with ethanol, acetone and other solvents |
Washing | 2-3BV/h | 3-4BV | Wash with plenty of water. |
Guidance for Selection of Macroporous Resin Adsorption Equipment1. Working Principle Macroporous resin is a kind of resin, which is different from ion exchange resin. Its surface and interior have voids corresponding to the molecular size of the adsorbed organic compounds, so it can be selectively adsorbed like molecular sieve. With the adsorption of Van der Waals gravity or hydrogen bond force of the resin itself, it can selectively adsorb specific structural compounds to achieve the purpose of separation and purification. Therefore, adsorption and screening is the fundamental mechanism for the separation and purification of macroporous resins.2. Adsorption Separation Process of Macroporous Resin The adsorption and separation process of macroporous resins for plant active ingredients is to fill macroporous resins in circular equipment. Like percolation equipment, macroporous resins are fixed bed equipment for liquid passing through static solid layer. When the macroporous resin is filled in the circular equipment, the following processes are carried out in turn:Resin pretreatment-- Activation of resin adsorption capacity;Adsorption -- Selective adsorption of some components in the extract of medicinal materials on macroporous resins;Solvent elution -- Dissolve some medicinal ingredients adsorbed on the resin into specific solvents flowing through the resin;Resin regeneration --Removing impurities in the resin and reactivating the adsorption capacity of the resin;Evaporative recovery solvents -- Eluents containing plant extracts are recovered by evaporation of solvents to obtain concentrated solutions of the extracts or dry resin adsorption products through crystallization, drying and other processes.3. Determination of Key Parameters in Macroporous Resin Adsorption and Separation Process3.1 Resin filling volume of adsorption equipment: According to the relevant data provided by resin manufacturers, combined with production process requirements, the amount of material adsorbed on the resin in each batch during operation can be calculated.3.2 Number of adsorption equipment:The number of adsorbents depends not only on the filling volume, but also on the length of production operation cycle, and the regeneration of resin.3.3 Diameter and height of macroporous resin equipment:According to the equipment pressure, equipment flow and site installation conditions, etc.3.4 Material of Resin Equipment: The material quality of resin equipment depends on the pretreatment and regeneration process of macroporous resin. If it does not involve dilute acid and alkali treatment, 304 or 316L stainless steel is generally selected. If dilute acid and alkali are involved, corrosion resistant plastic or iron plastic lining is considered.
Address:
Unit 3, Building 21, 4th District, Xiawang Village, Yiwu City, Jinhua, Zhejiang, China
Business Type:
Manufacturer/Factory, Trading Company
Business Range:
Industrial Equipment & Components, Manufacturing & Processing Machinery
Management System Certification:
ISO 9001, ISO 9000
Company Introduction:
Our company offers variety of products which can meetyour multifarious demands. We adhere to the management principles of " Qualityfirst, customer first and credit-based" Since theestablishment of the company and always do our best to satisfy potential needsof our customers. Our company is sincerely willing to cooperate withenterprises from all over the world in order to realize a win-win situationsince the trend of economic globalization has developed with anirresistible force.